Microbiology department, federal university of technology, p. Datura metel grows in the wild in all the warmer parts of the world, such as india and is cultivated worldwide for its chemical and ornamental properties. Studies on chemical constituents, phytochemical profile and pharmacological action of datura alba. Datura metel is a shrublike annual zone 57 or perennial zone 810 herb, commonly known in europe as indian thornapple, largeflowered thornapple, metel and in the u. Phytochemical screening of various fractions of datura alba showed bioactive. The therapeutic activities of most plants are due to the presence of one or more of such components like alkaloids, tannins, saponins and cardiac glycosides. Handbook of phytochemical constituents of gras herbs and other.
Cytotoxic withanolides from the flowers of datura metel. In this study, using the strategy chemical analysis, metabolism of single representative compounds, and metabolism of extract at clinical dosage that we propose here, 42 constituents were. Datura stramonium, medicinal, traditional, solanaceae, antiasthmatic. Datura is a genus of nine species of poisonous vespertine flowering plants belonging to the family solanaceae. Other english common names include moonflower, jimsonweed, devils weed. Click on a scientific name below to expand it in the plants classification report. Chemical constituents and pharmacological properties of. Jan 01, 2002 the indian thorn apple datura metel was first documented in sanskrit literature.
One steroidal constituent, daturasterol, and a tricyclic diterpene, daturabietatriene, have been isolated for the first time from the steam bark of datura metrel linn, along with bsitosterol and atropine. Characterization of the chemical constituents of datura metel. The present study was carried out to analyse the inorganic and organic contents in the leaf of datura metel and to investigate the acute toxicity at varying concentrations on grasshoppers and red ants. The investigation was carried out to determine the possible bioactive components of the flower of datura metel using gcms. Datura metel is well known for its insecticidal, herbicidal, antifungal, antibacterial, anticancer, antiinflammatory and antirheumatoid activity. Chemical investigation of 50% ethanol eluate fraction of macroporous resin for the flower of datura metel l.
Characterization, purification and identification of some. The antibacterial efficacy of crude aqueous and ethanol extracts leaf, stem bark and roots ofdatura metel at. Chemical constituents from the flower of datura metel. This plant was first described by carl linnaeus in 1753, but no. Methods the constituents were isolated and purified by silica gel,ods,and sephadex lh20 column chromatographies as well as hplc. They contain the potent anticholinergic substances scopolamine. Datura has long been known as a medicinal plant and as a plant hallucinogen all over the world. Datura metal, ppm datura metal, ppm chemical analysis of datura metel leaves 111 table 1. Pdf chemical constituents from the flower of datura metel. About ten species of datura are found, of which datura anoxia and d. This is the first report of the chemical constituents of the seeds of datura metel. The chemical compositions of the methanol extract of the flowerdatura metel were.
Pdf studies on chemical constituents, phytochemical profile. The indian thorn apple datura metel was first documented in sanskrit literature. They are commonly known as daturas, but also known as devils trumpets not to be confused with angels trumpets, which are contained in the closely related genus brugmansia. Characterization of the chemical constituents of datura. Daturas are known as powerful and dangerous deliriants, used for shamanic and medical purposes, as well as poisons.
Aderonke s aboluwodi, opeyemi n avoseh, oladipupo a lawal, isiaka a ogunwande and abdulateef a giwa abstract the chemical constituents and antiinflammatory activity of essential oils of datura stramonium l. In this study, using the strategy chemical analysis, metabolism of single representative compounds, and metabolism of extract at clinical dosage that we propose here, 42 constituents were characterized from d. College, ajmer abstract datura stramonium is a plant of medicinal plant family solananceae. Spectacular bloom and fragrance, not only boasts double trumpets of a unique mottled purple shade but also gives fragrance from spring through fall.
Their chemical structures were elucidated on the basis of spectral data. Chemical investigation of an acidic methanol extract of the whole plant of datura metel resulted in the isolation of seven compounds, including pterodontriol b 1, disciferitriol 2, scopolamine 3, adenosine 4, thymidine 5, ilekudinoside c 6, and dioscoroside d 7. Characterization, purification and identification of some alkaloids in datura stramonium abstract this study aimed at investigating the presence of alkaloids and other chemical constituents in datura stramonium saikaran, jimson weed. A stunningly beautiful garden datura, having huge double blossoms of an elegant lavender purple color. Antibacterial, phytochemical and antioxidant activities of datura metel akharaiyi, f. Characterization of the metabolic fate of datura metel seed. Introduction datura is a wild weed belonging to family solanaceae, its name derived from sanskrit word dhutra divine inebriation is used for its healing properties.
Effects of ethanolic extracts of leaf, seed and fruit of. As a result, two new withanolides 12 and one known withanolide 3 were isolated and identified from the etoacsoluble partition of its ethanol extract. Abstractthe essential oil from different parts of datura metel l. Publisher macmillan press year 1992 isbn 0333474945 description excellent and very comprehensive, though it contains a number of silly mistakes. Five known megastigmane sesquiterpenes were also isolated from d. Antibacterial, phytochemical and antioxidant activities of. New antiproliferative and immunosuppressive withanolides. They were collected in the polythene bags and brought to the. Chemical investigation of a methanol extract of the flowers of datura metel has led to the isolation of 10 new withanolides, withametelins i. Datura metel, purple hornofplenty, jimpson weed, devils. Chemical composition of the seeds of datura innoxia. Studies on chemical constituents, phytochemical profile. Datura metel is naturalised in all the warmer countries of the world notably in india and is cultivated worldwide, both as an ornamental and for its medicinal properties. Rashmi sharma3 research scholar1,2, associate professor3 zoology department, samrat prithviraj chauhan govt.
Chemical composition and cytotoxicity of the essential oil. Chemical constituents and antiinflammatory activity of. The chemical compositions of the methanol extract of the flowerdatura metel were investigated using perkinelmer gas chromatography mass spectrometry, while the mass spectra of the. Datura metel is a shrublike annual zone 57 or perennial zone 810 herb, commonly known as devils trumpet and metel. It consists of dried leaves and flowering tops of datura metal linn. The activities of the isolated compounds were also evaluated.
However, little is known on the chemical composition and in vivo metabolism of its seeds. Baimantuoluosides dg, four new withanolide glucosides. Zoology department, samrat prithviraj chauhan govt. Chemical constituents from the flower of datura metel l.
Objective to study the chemical constituents in the seeds of datura metel. Solanaceae is the widespread species of the genus datura, occurring in jiangsu, zhejiang, fujian, guangdong, and sichuan provinces of china. It is known for its antibacterial activity against burn pathogens 15,16. Characterization of the metabolic fate of datura metel.
Results the compounds were isolated from the etoac fraction of d. Datura, chemical constituents, alkaloids, biological activities, therapeutic usage. The arabic physician avicenna touted the importance of its medicinal applications as well as prescribed the exact amount of dosage to the arabs, who categorized the plant as mokederrat narcotica. Allelopathic effects of aqueous leaf extracts of datura metel. Solanaceae purple hornofplenty, jimpson weed, devils weed origin. Chemical analysis of datura metel leaves and investigation. Screening of bioactive components of the flower datura metel. It is 60120 cm or more tall, branched and pubescent plant. Chemical composition of the seeds of datura innoxia kendeson anawuese christiana p 1 p, iloka gabriel sunday p 2 p, bulama joshua samaila p 1 p and p p dashak albert dayil p 2 p. Chemical composition and cytotoxicity of the essential oil from different parts of datura metel l. Allelopathic effects of aqueous leaf extracts of datura. Abstract datura stramonium is a plant of medicinal plant family solananceae. Datura ferox, datura metel and datura stramonium were collected from the various localities of marathwada.
Extracted with 50% etoh, the constituents were isolated and purified by silica gel, ods and sephadex lh20 column chromatography as well as hplc. Studies on chemical constituents, phytochemical profile and pharmacological action of datura alba ghias uddin, abdur rauf and samina akhtar institute of chemical sciences, university of peshawar, peshawar25120, kpk, pakistan abstract. Screening of bioactive components of the flower datura. Screening of bioactive components of the flower datura metel using the gcms technology. Chemical constituents from the flower of datura metel article pdf available in archives of pharmacal research 319. Datura metel revealed the presence of alkaloids, tannins, cardiac glycosides, flavonoids, carbohydrates, amino acids and phenolic compounds, while, phytochemical analysis of datura stramonium showed that it contained alkaloids, saponins, tannins, steroids, flavonoids, phenols and glycosides. New antiproliferative and immunosuppressive withanolides from. The aim of the present study was to investigate allelopathic potential datura metel l. Chemical analysis of datura metel leaves and investigation of. In our search for bioactive antipsoriasis compounds from the flower of datura metel l, we isolated four new withanolide glucosides, baimantuoluosides d, e, f and g 14. Chemical constituents and antiinflammatory activity of essential oils of datura stramonium l. P 2 pdepartment of chemistry, university of jos, p.
Leaves are 817x4 cm, ovate, sinuately dentate and minutely puberulose. Their structures were elucidated by extensive spectroscopic methods, including 1d and 2d nmr and mass spectra. Pdf studies on chemical constituents, phytochemical. Quantitative measure of moisture, ash and organic matter of datura metel contents amount, % moisture 76. The datura plant is having high medicinal properties, it is given detail in the chapter no. Prehistoric use of datura in medicinal and ceremonial rituals could be observed in aboriginal in indian subcontinent. Various species of datura are known and widely employed for. The extract of datura metel was evaporated to dryness and the residue was heated on a boiling water bath with 2%. Brugmansia waymannii paxton, datura aegyptiaca vis. Jun 21, 2007 chemical investigation of a methanol extract of the flowers of datura metel has led to the isolation of 10 new withanolides, withametelins i. To study the chemical constituents of datura metel l. The fine powder of the plant parts were used for the chemical analysis. Effects of ethanolic extracts of leaf, seed and fruit of datura metel on kidney function of male albino rats was investigated in this study. Phytochemical investigation of the 50% ethanol eluate fraction of macroporous resin for the flower of datura metel l.
Datura also known as devils trumpet, moonflower, jimsonweed, devils weed, hells bells, thornapple, and many others is a genus of nine species of poisonous flowering plants belonging to the family solanaceae. Sep 01, 2008 five known megastigmane sesquiterpenes were also isolated from d. Introduction datura stramonium is commonly known as jimson weed or datura belongs to family solanaceae. Handbook of phytochemical constituents of gras herbs and other economic. Characterization of the chemical constituents of datura metel linn.
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